Antibodies, Vaccines and Immunity
Meiler Lab is expert in the field of structure-based reverse vaccinology. Starting from co-crystal structures of antigens and antibodies, we study in depth their interaction and we use the acquired knowledge to computationally design vaccines and antibodies. Thanks to our experience in the field of machine learning, we developed programs able to predict epitopes of interest in a series of viral glycoprotein and to computationally predict potential escape mutations. Moreover, we perform modeling of critical bio-molecules involved in defense and escaping of the immune system, such as CDR-H3 loops and viral glycans.
Vaccine Design
Computational design of vaccines has evolved rapidly over the course of the last decade, driven largely by the pursuit of an HIV vaccine. Researchers employ several strategies when developing vaccines but the shared objective is to ...
Antibody Design
Antibodies have become an increasingly relevant class of pharmaceutical modality in recent years owing to their quick development time. In 2018 seven out of the top 10 performing drugs were monoclonal antibodies or antibody conjugated drugs. ...
Antigen-Antibody Interactions
Antigen-antibody interaction is the study of the binding interface of antigen and antibody. This knowledge facilitates antibody design and vaccine development and enhances our understanding of the molecular mechanism of pathogenicity. To predict the interactions, we use RosettaDock framework.
Glycan Masking
Glycan Masking is a technique used in structure-based reverse vaccinology to focus the response of the immune system towards specific epitopes of interest. Glycans are added to the surface of potential vaccine candidates to hide epitopes that elicit poorly performing antibodies.
Epitope Predictions
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Antibody Loop Modeling
The complementary-determining regions (CDR) loops in heavy and light chain of antibodies play an important role in antigen recognition. However, the high variability in the CDR loop regions has posed a significant challenge ...
Escape mutant prediction
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