Computational design of biological systems promises to revolutionize the way we investigate and treat diseases, as well as how we approach materials engineering and chemical synthesis. I'm interested in developing methodologies to allow facile design of new biological systems, particularly those involving protein/small-molecule interactions. Currently I'm investigating structure-based techniques to allow us to propose new drug-like small molecules, which are designed to bind a given protein system. The hope is that such a general design system will allow straightforward creation of drug leads for systems involved in a range of diseases.