G546 Cosmis Score Q9NZ71-1

	Cosmis Score	pValue	cossyn	source
Normalized:	-0.64	0.33	0.24	SWISS-MODEL

MusiteDeep (PTMs) within 8.0A of G546

PTM Residue	PTM Type	Probability
543	Ubiquitination	0.6
586	N6-acetyllysine	0.6

Structure Summary

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	Q9NZ71-1_3_756_7o75.1.A	A	7o75.1.A		26.52	1.0			3	756			0.16	0.519	-0.03	0.598
modbase	ENSP00000359035.3_2	A	3crv		30.0	1.0			21	747			0.46	0.582	-0.02	0.243
modbase	ENSP00000359035.3_1	A	4a15		20.0	1.0			21	715			0.46	0.263	-0.02	0.269
modbase	ENSP00000359035.3_3	A	6fwr		21.0	1.0			204	714			0.0	0.341	0.12	0.443
alphafold	AF-Q9NZ71-F1	A			0.0	1.0	72.71	94.64	1	1219	2.03	0.12	0.06	0.385	0.01	0.301

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	Q9NZ71-1_3_756_7o75.1.A	A	7o75.1.A		26.52	1.0			3	756			0.16	0.519	-0.03	0.598

clinvar Results - Q9NZ71-1_3_756_7o75.1.A.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
2.25	5.00	1.42	13.00	0.72	0.52	0.16	0.99	0.06

COSMIC Results - Q9NZ71-1_3_756_7o75.1.A.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.86	10.00	0.82	20.00	0.75	0.60	-0.03	0.98	0.01

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000359035.3_2	A	3crv		30.0	1.0			21	747			0.46	0.582	-0.02	0.243

clinvar Results - ENSP00000359035.3_2.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
2.16	8.00	1.43	23.00	0.72	0.58	0.46	0.97	0.19

COSMIC Results - ENSP00000359035.3_2.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
2.10	9.00	-1.87	12.00	0.41	0.24	-0.02	0.99	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000359035.3_1	A	4a15		20.0	1.0			21	715			0.46	0.263	-0.02	0.269

clinvar Results - ENSP00000359035.3_1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
2.27	15.00	-1.05	41.00	0.61	0.26	0.46	0.90	0.25

COSMIC Results - ENSP00000359035.3_1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.78	15.00	-1.81	12.00	0.42	0.27	-0.02	0.99	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000359035.3_3	A	6fwr		21.0	1.0			204	714			0.0	0.341	0.12	0.443

clinvar Results - ENSP00000359035.3_3.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
2.18	45.00	3.11	5.00	0.64	0.34	0.00	1.00	0.00

COSMIC Results - ENSP00000359035.3_3.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.90	45.00	-1.32	45.00	0.65	0.44	0.12	0.87	0.17

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
alphafold	AF-Q9NZ71-F1	A			0.0	1.0	72.71	94.64	1	1219	2.03	0.12	0.06	0.385	0.01	0.301

clinvar Results - AF-Q9NZ71-F1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.46	45.00	1.68	12.00	0.70	0.38	0.06	1.00	0.02

COSMIC Results - AF-Q9NZ71-F1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.33	45.00	-1.23	15.00	0.57	0.30	0.01	1.00	0.01