Date | 2024-01-02 |
---|---|
Case | SampleCase |
Gene | RTEL1 |
Protein | Q9NZ71-6 |
Variant | G546D |
PTM Residue | PTM Type | Probability |
---|---|---|
543 | Ubiquitination | 0.6 |
586 | N6-acetyllysine | 0.6 |
Method | Structure Id | Chain | PDB Template |
PDB Resolution |
Template Identity |
Transcript Identity |
AF Global Quality |
AF Residue Confidence |
Seq Start |
Seq End |
ddG Monomer |
ddG Cartesian |
Pathprox clinvar |
Pathprox clinvar AOC |
Pathprox COSMIC |
Pathprox COSMIC AOC |
PDB Pos |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
swiss | Q9NZ71-6_3_757_8ebs.1.B | B | 8ebs.1.B | 25.66 | 1.0 | 3 | 757 | -0.01 | 0.386 | -0.01 | 0.263 |
Method | Structure Id | Chain | PDB Template |
PDB Resolution |
Template Identity |
Transcript Identity |
AF Global Quality |
AF Residue Confidence |
Seq Start |
Seq End |
ddG Monomer |
ddG Cartesian |
Pathprox clinvar |
Pathprox clinvar AOC |
Pathprox COSMIC |
Pathprox COSMIC AOC |
PDB Pos |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
swiss | Q9NZ71-6_3_757_8ebs.1.B | B | 8ebs.1.B | 25.66 | 1.0 | 3 | 757 | -0.01 | 0.386 | -0.01 | 0.263 |
Neutral Kz | Neutral Kt | Pathogenic Kz | Pathogenic Kt | ROC AUC | PR AUC | PathProx | Neutral Constraint | Pathogenic Constraint |
---|---|---|---|---|---|---|---|---|
1.74 | 7.00 | 1.57 | 10.00 | 0.65 | 0.39 | -0.01 | 1.00 | 0.00 |
Neutral Kz | Neutral Kt | Pathogenic Kz | Pathogenic Kt | ROC AUC | PR AUC | PathProx | Neutral Constraint | Pathogenic Constraint |
---|---|---|---|---|---|---|---|---|
1.32 | 7.00 | -1.61 | 10.00 | 0.42 | 0.26 | -0.01 | 1.00 | 0.00 |