Home Structure Report AF-Q9UBC0-F1 monomer
Date 2024-01-02
Case SampleCase
Gene ONECUT1
Protein Q9UBC0
Variant R269G

R269 Rate4Site Score ENST00000305901.7

Rate4Site Score QQ-Interval Std MSA
Normalized: -0.48 -0.63, -0.27 0.26 96.00/100

No MusiteDeep (PTMs) predicted within 8.0A of R269

ScanNet Prediction of R269 participation in a PPI

Binding Site Probability
0.3

Structure Summary

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
alphafold AF-Q9UBC0-F1 A 0.0 1.0 60.92 42.38 1 465 -2.92 -1.97 0.04 0.706

AF-Q9UBC0-F1.A monomer - Structure Detail

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
alphafold AF-Q9UBC0-F1 A 0.0 1.0 60.92 42.38 1 465 -2.92 -1.97 0.04 0.706

clinvar Results - AF-Q9UBC0-F1.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
3.05 5.00 0.00 0.00 0.00 0.00 0.00 1.00 0.00

COSMIC Results - AF-Q9UBC0-F1.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
3.55 5.00 2.35 29.00 0.77 0.71 0.04 1.00 0.01

Location of R269G in AF-Q9UBC0-F1.A (NGL Viewer)

Variant Distributions

63 gnomAD38
clinvar
No clinvar Variants map to this structure
31 COSMIC

Ripley's Univariate K

gnomAD38
clinvar
Ripley's Univariate K graphic was not created for clinvar
COSMIC

Ripley's Bivariate D

clinvar - gnomAD38
clinvar-gnomAD38 Bivariate D plot was not created
COSMIC - gnomAD38

PathProx (clinvar - gnomAD38) Results

PathProx
No graphic was created
PathProx clinvar ROC
No graphic was created
PathProx clinvar PR
No graphic was created

PathProx (COSMIC - gnomAD38) Results

PathProx
PathProx COSMIC ROC
PathProx COSMIC PR