D136 Cosmis Score P17050

	Cosmis Score	pValue	cossyn	source
Normalized:	3.13	1.00	-0.83	PDB

MusiteDeep (PTMs) within 8.0A of D136

PTM Residue	PTM Type	Probability
124	N-linked_glycosylation	0.9

ScanNet Prediction of D136 participation in a PPI

Binding Site Probability
0.2

Structure Summary

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P17050_19_404_1ktb.1.B	A	1ktb.1.B		74.87	1.0			19	404	-0.67	-0.08			-0.01	0.243
swiss	P17050_19_404_1ktb.1.B	A	1ktb.1.B		74.87	1.0			19	404					-0.01	0.243
modbase	ENSP00000379680.3_1	A	4do4		100.0	1.0			18	411	-0.66	0.37			0.11	0.364
alphafold	AF-P17050-F1	A			0.0	1.0	96.27	98.65	1	411	-2.36	0.78			-0.01	0.259
X-RAY	4do6	A		1.6		1.0			18	405					-0.01	0.252
X-RAY	4do4	B		1.4		1.0			18	411	-0.69	0.26			-0.01	0.251

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P17050_19_404_1ktb.1.B	A	1ktb.1.B		74.87	1.0			19	404	-0.67	-0.08			-0.01	0.243

clinvar Results - P17050_19_404_1ktb.1.B.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.38	5.00	0.00	0.00	0.00	0.00	0.00	0.97	0.00

COSMIC Results - P17050_19_404_1ktb.1.B.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.07	17.00	-1.41	8.00	0.36	0.24	-0.01	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P17050_19_404_1ktb.1.B	A	1ktb.1.B		74.87	1.0			19	404					-0.01	0.243

clinvar Results - P17050_19_404_1ktb.1.B.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.52	41.00	0.00	0.00	0.00	0.00	0.00	0.98	0.00

COSMIC Results - P17050_19_404_1ktb.1.B.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.62	41.00	-2.08	8.00	0.36	0.24	-0.01	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000379680.3_1	A	4do4		100.0	1.0			18	411	-0.66	0.37			0.11	0.364

clinvar Results - ENSP00000379680.3_1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.49	17.00	0.00	0.00	0.00	0.00	0.00	0.97	0.00

COSMIC Results - ENSP00000379680.3_1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.37	17.00	-1.24	24.00	0.62	0.36	0.11	0.92	0.12

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
alphafold	AF-P17050-F1	A			0.0	1.0	96.27	98.65	1	411	-2.36	0.78			-0.01	0.259

clinvar Results - AF-P17050-F1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
2.21	17.00	0.00	0.00	0.00	0.00	0.00	0.97	0.00

COSMIC Results - AF-P17050-F1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.94	17.00	-1.44	8.00	0.35	0.26	-0.01	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
X-RAY	4do6	A		1.6		1.0			18	405					-0.01	0.252

clinvar Results - 4do6.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.31	39.00	0.00	0.00	0.00	0.00	0.00	0.98	0.00

COSMIC Results - 4do6.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.44	39.00	-2.06	8.00	0.36	0.25	-0.01	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
X-RAY	4do4	B		1.4		1.0			18	411	-0.69	0.26			-0.01	0.251

clinvar Results - 4do4.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.31	17.00	0.00	0.00	0.00	0.00	0.00	0.97	0.00

COSMIC Results - 4do4.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.17	17.00	-1.39	8.00	0.35	0.25	-0.01	1.00	0.00