Date | 2024-01-02 |
---|---|
Case | SampleCase |
Gene | COA5 |
Protein | Q86WW8 |
Variant | P9L |
Rate4Site Score |
QQ-Interval |
Std |
MSA |
|
---|---|---|---|---|
Normalized: | -0.14 | -0.49, 0.07 | 0.44 | 76.00/100 |
Cosmis Score |
pValue |
cossyn |
source |
|
---|---|---|---|---|
Normalized: | 0.31 | 0.74 | 0.42 | AF2 |
PTM Residue |
PTM Type |
Probability |
---|---|---|
8 | N6-acetyllysine | 0.7 |
Binding Site Probability |
---|
0.3 |
Method |
Structure Id |
Chain |
PDB Template |
PDB Resolution |
Template Identity |
Transcript Identity |
AF Global Quality |
AF Residue Confidence |
Seq Start |
Seq End |
ddG Monomer |
ddG Cartesian |
Pathprox clinvar |
Pathprox clinvar AOC |
Pathprox COSMIC |
Pathprox COSMIC AOC |
PDB Pos |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
alphafold | AF-Q86WW8-F1 | A | 0.0 | 1.0 | 82.03 | 55.08 | 1 | 74 | 2.37 | 3.35 | -0.39 | 0.5 | |||||
swiss | Q86WW8_10_59_8e73.59.A | A | 8e73.59.A | 24.32 | 1.0 | 10 | 59 | 0.833 |
Method |
Structure Id |
Chain |
PDB Template |
PDB Resolution |
Template Identity |
Transcript Identity |
AF Global Quality |
AF Residue Confidence |
Seq Start |
Seq End |
ddG Monomer |
ddG Cartesian |
Pathprox clinvar |
Pathprox clinvar AOC |
Pathprox COSMIC |
Pathprox COSMIC AOC |
PDB Pos |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
alphafold | AF-Q86WW8-F1 | A | 0.0 | 1.0 | 82.03 | 55.08 | 1 | 74 | 2.37 | 3.35 | -0.39 | 0.5 |
Neutral Kz |
Neutral Kt |
Pathogenic Kz |
Pathogenic Kt |
ROC AUC |
PR AUC |
PathProx |
Neutral Constraint |
Pathogenic Constraint |
---|---|---|---|---|---|---|---|---|
1.54 | 27.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.93 | 0.00 |
Neutral Kz |
Neutral Kt |
Pathogenic Kz |
Pathogenic Kt |
ROC AUC |
PR AUC |
PathProx |
Neutral Constraint |
Pathogenic Constraint |
---|---|---|---|---|---|---|---|---|
1.53 | 27.00 | 1.67 | 18.00 | 0.67 | 0.50 | -0.39 | 0.90 | 0.00 |
Method |
Structure Id |
Chain |
PDB Template |
PDB Resolution |
Template Identity |
Transcript Identity |
AF Global Quality |
AF Residue Confidence |
Seq Start |
Seq End |
ddG Monomer |
ddG Cartesian |
Pathprox clinvar |
Pathprox clinvar AOC |
Pathprox COSMIC |
Pathprox COSMIC AOC |
PDB Pos |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
swiss | Q86WW8_10_59_8e73.59.A | A | 8e73.59.A | 24.32 | 1.0 | 10 | 59 | 0.833 |
Neutral Kz |
Neutral Kt |
Pathogenic Kz |
Pathogenic Kt |
ROC AUC |
PR AUC |
PathProx |
Neutral Constraint |
Pathogenic Constraint |
---|---|---|---|---|---|---|---|---|
-0.94 | 12.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
Neutral Kz |
Neutral Kt |
Pathogenic Kz |
Pathogenic Kt |
ROC AUC |
PR AUC |
PathProx |
Neutral Constraint |
Pathogenic Constraint |
---|---|---|---|---|---|---|---|---|
-0.94 | 12.00 | 1.64 | 10.00 | 0.87 | 0.83 | 0.00 | 0.00 | 0.00 |