Home Structure Report AF-Q86WW8-F1 monomer Q86WW8_10_59_8e73.59.A monomer
Date 2024-01-02
Case SampleCase
Gene COA5
Protein Q86WW8
Variant P9L

P9 Rate4Site Score ENST00000328709.8

Rate4Site Score QQ-Interval Std MSA
Normalized: -0.14 -0.49, 0.07 0.44 76.00/100

P9 Cosmis Score Q86WW8

Cosmis Score pValue cossyn source
Normalized: 0.31 0.74 0.42 AF2

MusiteDeep (PTMs) within 8.0A of P9

PTM Residue PTM Type Probability
8 N6-acetyllysine 0.7

ScanNet Prediction of P9 participation in a PPI

Binding Site Probability
0.3

Structure Summary

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
alphafold AF-Q86WW8-F1 A 0.0 1.0 82.03 55.08 1 74 2.37 3.35 -0.39 0.5
swiss Q86WW8_10_59_8e73.59.A A 8e73.59.A 24.32 1.0 10 59 0.833

AF-Q86WW8-F1.A monomer - Structure Detail

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
alphafold AF-Q86WW8-F1 A 0.0 1.0 82.03 55.08 1 74 2.37 3.35 -0.39 0.5

clinvar Results - AF-Q86WW8-F1.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
1.54 27.00 0.00 0.00 0.00 0.00 0.00 0.93 0.00

COSMIC Results - AF-Q86WW8-F1.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
1.53 27.00 1.67 18.00 0.67 0.50 -0.39 0.90 0.00

Location of P9L in AF-Q86WW8-F1.A (NGL Viewer)

Variant Distributions

9 gnomAD38
1 clinvar
3 COSMIC

Ripley's Univariate K

gnomAD38
clinvar
Ripley's Univariate K graphic was not created for clinvar
COSMIC

Ripley's Bivariate D

clinvar - gnomAD38
clinvar-gnomAD38 Bivariate D plot was not created
COSMIC - gnomAD38

PathProx (clinvar - gnomAD38) Results

PathProx
No graphic was created
PathProx clinvar ROC
No graphic was created
PathProx clinvar PR
No graphic was created

PathProx (COSMIC - gnomAD38) Results

PathProx
PathProx COSMIC ROC
PathProx COSMIC PR

Q86WW8_10_59_8e73.59.A.A monomer - Structure Detail

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
swiss Q86WW8_10_59_8e73.59.A A 8e73.59.A 24.32 1.0 10 59 0.833

clinvar Results - Q86WW8_10_59_8e73.59.A.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
-0.94 12.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00

COSMIC Results - Q86WW8_10_59_8e73.59.A.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
-0.94 12.00 1.64 10.00 0.87 0.83 0.00 0.00 0.00

Location of P9L in Q86WW8_10_59_8e73.59.A.A (NGL Viewer)

Variant Distributions

5 gnomAD38
1 clinvar
3 COSMIC

Ripley's Univariate K

gnomAD38
clinvar
Ripley's Univariate K graphic was not created for clinvar
COSMIC

Ripley's Bivariate D

clinvar - gnomAD38
clinvar-gnomAD38 Bivariate D plot was not created
COSMIC - gnomAD38

PathProx (clinvar - gnomAD38) Results

PathProx
No graphic was created
PathProx clinvar ROC
No graphic was created
PathProx clinvar PR
No graphic was created

PathProx (COSMIC - gnomAD38) Results

PathProx
PathProx COSMIC ROC
PathProx COSMIC PR