Home Structure Report ENSP00000495274.1_2 monomer
Date 2024-01-02
Case SampleCase
Gene AP3D1
Protein O14617-5
Variant V699M

MusiteDeep (PTMs) within 8.0A of V699

PTM Residue PTM Type Probability
696 Phosphothreonine 0.7

Structure Summary

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
modbase ENSP00000495274.1_2 A 4pjw 14.0 1.0 313 1019 0.03 0.299

ENSP00000495274.1_2.A monomer - Structure Detail

Method Structure Id Chain PDB
Template		 PDB
Resolution		 Template
Identity		 Transcript
Identity		 AF Global
Quality		 AF Residue
Confidence		 Seq
Start		 Seq
End		 ddG
Monomer		 ddG
Cartesian		 Pathprox
clinvar		 Pathprox
clinvar AOC		 Pathprox
COSMIC		 Pathprox
COSMIC AOC		 PDB
Pos
modbase ENSP00000495274.1_2 A 4pjw 14.0 1.0 313 1019 0.03 0.299

clinvar Results - ENSP00000495274.1_2.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
-2.28 11.00 0.00 0.00 0.00 0.00 0.00 0.97 0.00

COSMIC Results - ENSP00000495274.1_2.A

Neutral Kz Neutral Kt Pathogenic Kz Pathogenic Kt ROC AUC PR AUC PathProx Neutral Constraint Pathogenic Constraint
-2.33 11.00 -1.90 14.00 0.46 0.30 0.03 0.98 0.03

Location of V699M in ENSP00000495274.1_2.A (NGL Viewer)

Variant Distributions

134 gnomAD38
clinvar
No clinvar Variants map to this structure
34 COSMIC

Ripley's Univariate K

gnomAD38
clinvar
Ripley's Univariate K graphic was not created for clinvar
COSMIC

Ripley's Bivariate D

clinvar - gnomAD38
clinvar-gnomAD38 Bivariate D plot was not created
COSMIC - gnomAD38

PathProx (clinvar - gnomAD38) Results

PathProx
No graphic was created
PathProx clinvar ROC
No graphic was created
PathProx clinvar PR
No graphic was created

PathProx (COSMIC - gnomAD38) Results

PathProx
PathProx COSMIC ROC
PathProx COSMIC PR