MusiteDeep (PTMs) within 8.0A of A269

PTM Residue	PTM Type	Probability
355	Methylarginine	0.7

Structure Summary

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P22557-4_130_565_6hrh.1.A	B	6hrh.1.A		99.78	1.0			130	565	22.93	10.41	0.46	0.966	0.03	0.527
swiss	P22557-4_130_565_6hrh.1.A	B	6hrh.1.A		99.78	1.0			130	565			0.06	0.797	0.02	0.494
modbase	ENSP00000379501.3_2	A	5qr1		99.0	1.0			127	565	17.04	11.29	0.5	0.958	-0.01	0.471
modbase	ENSP00000379501.3_3	A	5txt		37.0	1.0			130	534			0.37	0.908	0.03	0.498
modbase	ENSP00000379501.3_4	A	2bwn		50.0	1.0			131	527	2.39	2.81	0.29	0.874	-0.02	0.479
X-RAY	5qqr	A		1.46		1.0			130	565			0.0	0.784	0.07	0.507
X-RAY	5qqr	B		1.46		1.0			130	565	23.86	8.74	0.23	0.954	0.14	0.53

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P22557-4_130_565_6hrh.1.A	B	6hrh.1.A		99.78	1.0			130	565	22.93	10.41	0.46	0.966	0.03	0.527

clinvar Results - P22557-4_130_565_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.46	39.00	2.57	34.00	0.97	0.97	0.46	0.85	0.30

COSMIC Results - P22557-4_130_565_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.46	36.00	-1.07	11.00	0.55	0.53	0.03	1.00	0.02

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P22557-4_130_565_6hrh.1.A	B	6hrh.1.A		99.78	1.0			130	565			0.06	0.797	0.02	0.494

clinvar Results - P22557-4_130_565_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.39	32.00	2.38	15.00	0.85	0.80	0.06	0.99	0.03

COSMIC Results - P22557-4_130_565_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.09	32.00	-1.50	11.00	0.54	0.49	0.02	1.00	0.01

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000379501.3_2	A	5qr1		99.0	1.0			127	565	17.04	11.29	0.5	0.958	-0.01	0.471

clinvar Results - ENSP00000379501.3_2.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.14	38.00	2.67	33.00	0.97	0.96	0.50	0.87	0.30

COSMIC Results - ENSP00000379501.3_2.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.08	38.00	-1.10	8.00	0.49	0.47	-0.01	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000379501.3_3	A	5txt		37.0	1.0			130	534			0.37	0.908	0.03	0.498

clinvar Results - ENSP00000379501.3_3.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.71	8.00	1.16	37.00	0.92	0.91	0.37	0.81	0.32

COSMIC Results - ENSP00000379501.3_3.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.72	8.00	-1.49	11.00	0.45	0.50	0.03	1.00	0.02

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000379501.3_4	A	2bwn		50.0	1.0			131	527	2.39	2.81	0.29	0.874	-0.02	0.479

clinvar Results - ENSP00000379501.3_4.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-1.97	25.00	2.51	26.00	0.86	0.87	0.29	0.92	0.18

COSMIC Results - ENSP00000379501.3_4.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-1.93	27.00	-1.61	9.00	0.44	0.48	-0.02	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
X-RAY	5qqr	A		1.46		1.0			130	565			0.0	0.784	0.07	0.507

clinvar Results - 5qqr.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.70	36.00	1.97	15.00	0.83	0.78	0.00	0.98	0.02

COSMIC Results - 5qqr.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.33	34.00	-1.58	11.00	0.53	0.51	0.07	1.00	0.02

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
X-RAY	5qqr	B		1.46		1.0			130	565	23.86	8.74	0.23	0.954	0.14	0.53

clinvar Results - 5qqr.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.55	38.00	2.39	33.00	0.96	0.95	0.23	0.89	0.19

COSMIC Results - 5qqr.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.48	36.00	-1.20	11.00	0.54	0.53	0.14	1.00	0.05