No MusiteDeep (PTMs) predicted within 8.0A of A245

Structure Summary

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P22557-2_106_541_6hrh.1.A	B	6hrh.1.A		99.78	1.0			106	541	23.22	9.71	0.46	0.966	0.03	0.527
swiss	P22557-2_106_541_6hrh.1.A	B	6hrh.1.A		99.78	1.0			106	541			0.06	0.797	0.02	0.494
modbase	ENSP00000337131.4_1	A	5qr1		99.0	1.0			103	541	17.06	11.32	0.5	0.958	-0.01	0.471
modbase	ENSP00000337131.4_2	A	5txt		37.0	1.0			106	510			0.37	0.908	0.03	0.498
modbase	ENSP00000337131.4_3	A	2bwn		50.0	1.0			107	503	2.3	2.97	0.29	0.874	-0.02	0.479
X-RAY	5qqr	A		1.46		1.0			106	541			-0.03	0.784	-0.02	0.507
X-RAY	5qqr	B		1.46		1.0			106	541	23.86	8.74	0.31	0.954	-0.03	0.53

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P22557-2_106_541_6hrh.1.A	B	6hrh.1.A		99.78	1.0			106	541	23.22	9.71	0.46	0.966	0.03	0.527

clinvar Results - P22557-2_106_541_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.46	39.00	2.56	34.00	0.97	0.97	0.46	0.85	0.30

COSMIC Results - P22557-2_106_541_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.47	36.00	-1.06	11.00	0.55	0.53	0.03	1.00	0.02

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
swiss	P22557-2_106_541_6hrh.1.A	B	6hrh.1.A		99.78	1.0			106	541			0.06	0.797	0.02	0.494

clinvar Results - P22557-2_106_541_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.42	32.00	2.38	15.00	0.85	0.80	0.06	0.99	0.03

COSMIC Results - P22557-2_106_541_6hrh.1.A.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.10	32.00	-1.50	11.00	0.54	0.49	0.02	1.00	0.01

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000337131.4_1	A	5qr1		99.0	1.0			103	541	17.06	11.32	0.5	0.958	-0.01	0.471

clinvar Results - ENSP00000337131.4_1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.14	38.00	2.66	33.00	0.97	0.96	0.50	0.87	0.30

COSMIC Results - ENSP00000337131.4_1.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.09	38.00	-1.09	8.00	0.49	0.47	-0.01	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000337131.4_2	A	5txt		37.0	1.0			106	510			0.37	0.908	0.03	0.498

clinvar Results - ENSP00000337131.4_2.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.71	8.00	1.14	37.00	0.92	0.91	0.37	0.81	0.32

COSMIC Results - ENSP00000337131.4_2.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
1.71	8.00	-1.49	11.00	0.45	0.50	0.03	1.00	0.02

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
modbase	ENSP00000337131.4_3	A	2bwn		50.0	1.0			107	503	2.3	2.97	0.29	0.874	-0.02	0.479

clinvar Results - ENSP00000337131.4_3.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-1.98	25.00	2.51	26.00	0.86	0.87	0.29	0.92	0.18

COSMIC Results - ENSP00000337131.4_3.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-1.94	27.00	-1.61	9.00	0.44	0.48	-0.02	1.00	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
X-RAY	5qqr	A		1.46		1.0			106	541			-0.03	0.784	-0.02	0.507

clinvar Results - 5qqr.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.68	36.00	1.97	15.00	0.83	0.78	-0.03	0.98	0.01

COSMIC Results - 5qqr.A

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-3.33	34.00	-1.58	11.00	0.53	0.51	-0.02	0.99	0.00

Method	Structure Id	Chain	PDB Template	PDB Resolution	Template Identity	Transcript Identity	AF Global Quality	AF Residue Confidence	Seq Start	Seq End	ddG Monomer	ddG Cartesian	Pathprox clinvar	Pathprox clinvar AOC	Pathprox COSMIC	Pathprox COSMIC AOC	PDB Pos
X-RAY	5qqr	B		1.46		1.0			106	541	23.86	8.74	0.31	0.954	-0.03	0.53

clinvar Results - 5qqr.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.55	38.00	2.40	33.00	0.96	0.95	0.31	0.88	0.22

COSMIC Results - 5qqr.B

Neutral Kz	Neutral Kt	Pathogenic Kz	Pathogenic Kt	ROC AUC	PR AUC	PathProx	Neutral Constraint	Pathogenic Constraint
-2.50	36.00	-1.20	11.00	0.54	0.53	-0.03	0.99	0.00