Date	2024-01-02
Case	SampleCase
Log Files	Click for log files

Data Preprocessing Logs
VUstruct Phase	Start Time	End Time	Log
parse_udn_report.py	2024-01-02T05:45:37.128078	2024-01-02T05:45:48.911892	Log File
vustruct_plan.py	2024-01-02T05:46:17.816119	2024-01-02T05:46:59.359806	Log File
vustruct_launch.py	2024-01-02T05:47:12.215992	2024-01-02T05:47:16.065710	Log File

SampleCase

#	Gene	Chrom	Pos	Variant		PP clinvar		PP COSMIC		ddg Monomer		ddg Cartesian		Gene Interactions
	Protein Unp ID	Transcript Refseq	Transcript ENSEMBL	Prot Change	Amino Acid Length	Min	Max	Min	Max	Min	Max	Min	Max	Generic	Familial	Notes
0	COA5	chr2	98608380	G/A	74			-0.39	-0.39	2.37	2.37	3.35	3.35
Report	Q86WW8	NM_001008215.2	ENST00000328709.8	P9L	74			-0.39	-0.39	2.37	2.37	3.35	3.35
1	NAGA	chr22	42067209	C/T	411			-0.01	0.11	-2.36	-0.66	-0.08	0.78
Report	P17050	NM_000262.2	ENST00000396398.8...	D136N	411			-0.01	0.11	-2.36	-0.66	-0.08	0.78
2	SMYD5	chr2	73218934	C/A	418			0.01	0.05	27.1	27.1	7.34	7.34
Report	Q6GMV2	NM_006062.2	ENST00000389501.9	A57E	418			0.01	0.05	27.1	27.1	7.34	7.34
3	SMARCAL1	chr2	216447069	G/A	954	0.06	0.47	-0.03	0.31	0.67	4.43	-0.13	10.3
Report	Q9NZC9	NM_001127207.1	ENST00000357276.9...	A588T	954	0.06	0.47	-0.03	0.31	0.67	4.43	-0.13	10.3
4	ONECUT1	chr15	52789080	G/C	465			0.04	0.04	-2.92	-2.92	-1.97	-1.97
Report	Q9UBC0	NM_004498.2	ENST00000305901.7	R269G	465			0.04	0.04	-2.92	-2.92	-1.97	-1.97
5	ALAS2	chrX	55017645	C/T	550-587	-0.03	0.5	-0.03	0.14	0.42	23.86	2.81	11.32
Report	P22557-1	NM_000032.4	ENST00000650242.1	A282T	587	0.06	0.5	-0.02	0.03	0.42	23.53	2.81	10.58
Report	P22557-2	NM_001037967.3	ENST00000335854.8	A245T	550	-0.03	0.5	-0.03	0.03	2.3	23.86	2.97	11.32
Report	P22557-4	NM_001037968.3	ENST00000396198.7	A269T	574	0.0	0.5	-0.02	0.14	2.39	23.86	2.81	11.29
8	AP3D1	chr19	2115592	C/T	1153-1215			-0.07	0.03	-0.95	-0.5	-0.08	0.26
Report	O14617-1	NM_003938.6	ENST00000345016.9	V699M	1153			-0.07	-0.01	-0.95	-0.5	-0.08	0.26
Report	O14617-5	NM_001261826.1	ENST00000643116.3	V699M	1215			0.03	0.03
10	RTEL1	chr20	63688301	G/A	996-1300	-0.01	0.49	-0.03	0.12	2.03	2.03	0.12	0.12
Report	Q9NZ71-1	NM_016434.3	ENST00000370018.7	G546D	1219	0.0	0.46	-0.03	0.12	2.03	2.03	0.12	0.12
Report	Q9NZ71-6	NM_001283009.1	ENST00000360203.11	G546D	1300	-0.01	-0.01	-0.01	-0.01
Report	Q9NZ71-7	NM_032957.4	ENST00000508582.7	G570D	1243	0.16	0.49	-0.01	-0.01
Report	Q9NZ71-8	NA	ENST00000482936.6	G546D	1004
Report	Q9NZ71-9	NM_001283010.1	ENST00000318100.9	G323D	996	0.23	0.35	-0.02	0.01

DiGePred Analysis

Top Scoring DiGePred Gene Pairs

DiGePred Score	Gene A	Gene B
0.547	COA5	NAGA
0.166	AP3D1	NAGA
0.14	COA5	RTEL1
0.0762	ALAS2	COA5
0.0759	COA5	SMARCAL1
0.0753	NAGA	SMARCAL1
0.0531	NAGA	RTEL1
0.0368	RTEL1	SMARCAL1
0.019	RTEL1	SMYD5
0.0182	ALAS2	RTEL1
0.0166	COA5	ONECUT1
0.00898	AP3D1	SMARCAL1
0.00824	NAGA	ONECUT1
0.00626	ONECUT1	RTEL1
0.00603	ONECUT1	SMARCAL1
0.00435	AP3D1	RTEL1
0.00434	ALAS2	ONECUT1
0.00316	NAGA	SMYD5
0.00203	ALAS2	SMARCAL1
0.000479	AP3D1	COA5

DIEP Digenic Interaction Analysis Heatmap